Somatic symptom disorder (SSD) is a clinical syndrome characterized by the presence of multiple unexplained physical complaints without a known physical cause. This disorder is an important condition in primary care because it is responsible for unnecessary diagnostic testing and therapeutic interventions. It is important to distinguish SSD from complaints that occur in patients with coexisting anxiety disorders. Complaints associated with panic attacks are likely to be identified with the panic or anxiety; in contrast, in patients with SSD, physical complaints tend to be the primary complaint. Cognitive-behavioral therapy (CBT) is a well-established treatment for patients with somatic symptoms. Pharmacological options for therapy include the judicious use of antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). Mental health providers also can provide a better assessment of the patient’s improvement if they are brought in early so they have an understanding of the baseline symptomology.