Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) are neoplasms of lymphocytes and affect the anatomical sites where these cells develop and are processed, including the lymph nodes, the spleen, and the hematopoietic system. These cancers may spread to other tissues and structures, including the gastrointestinal tract, bone marrow, and liver. Lymphomas are considered cancers of the immune system, as they arise from the proliferation and accumulation of a mature single clone of lymphocytes. Primary care providers represent a vital piece in the care of patients with lymphoma, particularly in coordinating their cancer treatments with their chronic conditions and emphasizing evidence-based, effective, and safe supportive care of the patient’s symptoms and wellness. The treatment regimens for aggressive lymphomas result in potentially severe side effects and toxicities. Patients need education regarding the specific toxicities of the chemotherapeutic agents in their regimen.