This chapter discusses health promotion from the perspective of patient-centered care, including screening for early indicators of disease and advocating for overall wellness. Effectiveness should be the most basic requirement for providing any health care service. This includes health-promotion activities, where the health care provider has the ethical responsibility to “do no harm” to patients. Providers must understand the sensitivity, specificity, and reliability underlying disease prevalence and relative cost of screening before incorporating a screening process into a patient’s wellness plan. Milestones of the young adult, middle adult, and older adult stages help to provide a framework for health promotion and disease prevention activities. High-risk behavior has been associated with a multitude of disease states and injuries. In many cases, individuals are involved in multiple high-risk behaviors, such as smoking and drinking, and driving while intoxicated.