Primary care providers make clinical decisions on a daily basis. The translation of health research into usable evidence can help reduce this uncertainty in clinical practice. The evidence-based practice (EBP) movement came to fruition in 1992 when the term evidence-based medicine was coined by Gordon Guyatt and colleagues of McMaster University. Many primary care providers turn to systematic reviews and clinical practice guidelines (CPGs) that summarize available evidence in a more readily accessible format. High-quality evidence-based CPGs have the ability to improve clinical outcomes and health policy. CPGs are developed to guide clinical practice and decision making. Given the growing number of CPGs available, it is important that primary care providers be able to critically appraise the process used to develop a guideline, as well as the applicability, flexibility, and clarity of the recommendations provided.