American Indians in the United States have a long history of repeated trauma exposure. They experience adverse events at a higher rate than what has been reported in general surveys of non-Native Americans. As a result, they experience high instances of reported substance abuse, mental health concerns, and exposure to violence. American Indians are at higher risk for posttraumatic stress disorder (PTSD) due to pervasive trauma exposure. Consideration for the use of eye movement desensitization and reprocessing (EMDR) therapy must take into account the cultural variances of this resilient and diverse group(s) of people. Trust is a complex, long-term, and dynamic process that modern treatment providers need to take into consideration when working with this population. A brief history of past and modern experiences is reviewed and recommendations for culturally informed trauma therapies are listed. Indigenous peoples are good candidates for EMDR therapy.