Nurses who engage in evidence-based practice (EBP) report heightened motivation, autonomy, and clinical expertise. Empowered nurses are generally employed in healthy work environments that provide organizational structure for participant empowerment. Healthy work environments manifest attributes of interprofessional collaboration, effective communication, accountability, shared clinical decision making, and visible, dependable organizational leadership. Nurses working in healthy organizations often report a greater sense of empowerment. This chapter describes ways nurses are expected to act when empowered to solve patient care problems and promote positive healthcare decisions. It reviews how empowered nurses birth new ideas and innovations and engage in EBP to contribute and utilize new knowledge for the advancement of patient care. The chapter emphasizes how nursing leadership and those who practice professional nursing are responsible for setting up cultures of care that empower nurses to engage in EBP.