This chapter helps the reader to explain the significance of clinical practice guidelines (CPGs), describe the relationship between CPGs and evidence-based practice (EBP) and to describe the Institute of Medicine (IOM) standards for CPG development. It also helps the reader to discuss CPG appraisal and implementation and identify factors that promote or inhibit CPG adoption. Nurses are demonstrating commitment to EBP and the most effective methods for translating appropriate evidence into a clinical context. CPGs are an effective method to facilitate appropriate patient-centered care based on best evidence and broad expert consensus. The nurse and healthcare organization deciding to use a guideline must ensure the CPG was developed appropriately using a standardized and acceptable methodology. By understanding the factors that influence adoption and utilization of a CPG, better planning for implementation in the clinical setting can occur.