This chapter describes efficient and effective research literature techniques that nurses may easily use independently. It emphasizes the important and growing collaborative role health science librarians and nurses are cultivating to maximize the use of electronic and digital resources to provide the best patient-centered care. The nursing discipline typically uses a twofold process to help identify and evaluate the worth of evidence: (a) level of evidence and (b) quality of evidence. This process is indispensable in helping nurses determine the best evidence to use in answering patient population, intervention, comparison, outcome, time frame [PICOT] questions and has utility related to ease of use for nurses. The chapter discusses historical development, logical sequencing, and use of levels of evidence. It then explores the assessment of quality of evidence as a means to further select the most sound and relevant evidence to answer PICOT questions and support the implementation of patient-centered care.