Patient-Centered Medical Homes are models of practice that seek to improve healthcare quality and patient engagement through enhanced technology and care coordination within primary care. Use of the medical home is an approach that is patient-centered and supports patients and families by assisting them to manage healthcare decisions and involving them in their care planning. The primary care team helps patients follow their plans of care, thereby meeting their goals using coaching and advising techniques. There is also opportunity for the medical home to connect patients with peers in the community who share similar health issues and experiences to provide support and encouragement. Medical homes have infrastructure to coordinate care and provide support to patients with chronic conditions such as stroke. This chapter describes the prevalence and effects of stroke and how practicing in a medical home model can provide secondary and tertiary prevention strategies to assist in stroke recovery.