During this century, people will live longer as evidenced by the current life expectancy of 76 years for men and 83 years for women. The prospect of living longer means that more people will be susceptible to chronic illnesses with the likelihood of developing more than one chronic illness requiring management, resulting in costly treatments. The U.S. healthcare system is focused on episodic and reactive care, which raises healthcare dollars. The focus of healthcare should be on prevention and behavior modification. There are multiple modifiable risk factors for coronary artery disease. In population health, overall prevention of disease should include primordial and primary prevention. Nurses have the greatest influence on primary care through prevention measures such as health teaching, counseling, and interprofessional collaboration. These efforts will improve patient engagement and motivation to change the client’s behavior and will likely prevent chronic diseases among at-risk populations.