This chapter reviews the intersectionality of ethnicity, race, and culture as they materialize within the dynamics of clinical supervision. Considerations regarding best practices are raised, and there is discussion regarding the harm that could emerge if culturally responsive supervision is not secured, broached, or discussed within the clinical supervisory relationship. Also reviewed are critical elements that the counselor-in-training (CIT) will need to navigate during their development as a culturally responsive, culturally humble, and empathic supervisor and mental health professional. CITs must understand their personhood to be able to respond responsibly and with cultural humility when helping clients. Key terminology related to multicultural counseling is included. This chapter discusses best practices and ethical considerations in multicultural counseling, including the responsibilities in supervision and training. Lastly, central to finding and establishing a healthy working alliance within the clinical supervisory relationship is identifying the negative impact that the power and responsibility held by the clinical supervisor may have on the clinical supervisory relationship.