The interprofessional simulation in this chapter is ideal for nursing students in prelicensure baccalaureate, registered nurse (RN)-to-Bachelor of Science in Nursing (BSN) students, or graduate programs. It serves pharmacy, respiratory, or medical students and is appropriate for a professional development activity for health care professionals responding to cardiac emergencies. St. John’s College of Nursing in Springfield, Illinois, offers this simulation in the baccalaureate program to medical-surgical students during their penultimate semester in the program, after completion of two other medical-surgical courses spiraled in difficulty. This simulation-based pedagogy allows evidence-based practice in a faculty-supported environment where students can gain confidence and learn from their actions, as well as by observing interprofessional peers. Respiratory care students complete the advanced cardiovascular life support (ACLS) provider course before this interprofessional education (IPE) and have additional prereading about cardiovascular resuscitation.