Nurses are the largest sector of health professionals and the most trusted around the world. All nurses are facing challenges with one or more sectors of the populations they serve (e.g., maternal child, aging, mental health) because of the large impact of the social determinants of health on healthcare beyond simple access to clinical care and services. Nurses hold a unique role to improve health and contribute to the current and future development goals outlined by the United Nations. This chapter examines the social responsibility of nursing in the context of global health policy, describes collaborative strategies designed to advance the nursing profession internationally, and explores the role of the nurse as a global citizen. It helps readers to identify common issues that unite nurses globally and to compare and contrast key international organizations relevant to health and nursing policy.