This chapter recognizes how men who have sex with men (MSM) are currently living at the intersection of two epidemics–one involving HIV/AIDS and another involving methamphetamine (MA) drug use. It offers recommendations for researchers and clinicians working with this special population. The chapter discusses the range of health disparities impacting MSM to place their lives in context. It describes recruitment and study participation issues with MSM communities and clinical treatment issues with MSM using methamphetamine Health care access disparities are more emphasized among MSM of color who may have a more difficult time due to socioeconomic status, insurance status, as well as fear of stigma and disclosure by health care providers. Reaching out to and communicating with MSM communities require cultural sensitivity, cultural competence, and replacing any maladaptive responses with adaptive responses, such as acceptance, respect, and empathy–going well beyond tolerance.