Design thinking is a process that cannot function under the same constraints that have been built around more linear and quantitative approaches in healthcare. It requires a different ecosystem, one that allows for and embeds empathetic engagement, radical collaboration, and rapid prototyping. Design thinking is an action-oriented problem-solving framework. This chapter helps the reader to: define design thinking and describe its role in healthcare leadership, innovation, and practice; develop an understanding of how design thinking relates to, and complements, other effective management and practice approaches; develop comfort in, and a way to navigate, ambiguity and unknowns; and describe strategies for successful implementation of design principles and practices within their own practice/organization. Design thinking yields increased systematic understanding of a problem and its possible solutions because it starts, and is driven by, key stakeholder’s lived experience(s), which cut across sectoral, social, geographical, and political boundaries.