Classroom engagements and lessons are an important part of the role of school counselors. Classroom guidance allows for systemic change and collaboration with the teachers. Classroom guidance should be implemented in PK–12 settings and focus on academics, career, and personal/social domains consistent with a comprehensive school counseling program. This chapter will focus on developmentally appropriate and culturally relevant classroom guidance lessons/presentations for each level of school counseling. A discussion of relevance, scholarly support, best practice, classroom management strategies and practical application will be provided.