Asian Americans (AAs) are now the fastest growing minority group in the United States. Although the median household income among AAs is higher than the national average, more AAs remain in poverty. Using an ecological perspective, Ma and Daus developed a comprehensive framework to guide health intervention and programming among AAs. This multilevel framework is useful for understanding health disparities among AAs and includes the following levels: individual, family, community, organization, government, and society. This chapter focuses on the individual, organization, and government levels. It describes the ways in which immigration policies have shaped the demographic profile of Asian Americans. The chapter then discusses ways in which social determinants of health relate to Asian health disparities. It summarizes the disparities in morbidity and mortality faced by Asian populations in the United States. The chapter then articulates how community-based participatory research is a particularly effective approach in working with Asian populations.