Health policies that support the uptake and dissemination of effective HIV/AIDS primary and secondary prevention programs and strategies are essential. However, as was true since the beginning of the epidemic, HIV/AIDS research and policy are challenging due to the racism, discrimination, stigma, and homophobia associated with the disease. The effectiveness of HIV/AIDS prevention has been consistently demonstrated in rigorous randomized clinical trials, implemented in practice, and supported through effective policies. This chapter explains how prevention research has been used to support policy in preventing HIV in communities of color. It discusses how the development of evidence-based programs has been disseminated to schools, communities, and practitioners through the development of effective national and local policy. The chapter describes the importance of advocacy organizations in promoting effective programs and policies. It focuses on research conducted with African American and Latino adolescents.