Youth suicide is a significant public health problem both in the United States and in other countries. Evidence-based interventions for youth suicidal behavior include both community- and school-based approaches. Suicidal behavior which includes suicidal ideation, suicide-related communication, suicide attempts, and suicide represents a continuum of behaviors that affects hundreds of thousands of adolescents, young adults, and their friends and families each year. This chapter discusses several of these interventions, social, crisis hotlines and social media, psychopharmacological interventions, hospitalization, dialectical behavior therapy (DBT), and school-based suicide prevention programs. School-based mental health professionals are typically the most appropriate persons to lead universal information sessions. The chapter provides a brief guide to the implementation of a school-based, three-tier model of youth suicide prevention. Students who are identified as being at risk of suicidal behavior typically have significant mental health problems, particularly mood disorders, substance-related disorders and disruptive behavioral problems, respectively.