A diagnosis of schizophrenia is terrifying and demoralizing to both the client and family members and has, until recently, been associated with dread and despair, the anticipation of a lifetime of chronic struggle, and a bewildering journey through the quagmire of psychiatric institutions and treatments. This chapter focuses on schizophrenia while noting the additional psychotic disorders in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) for the purpose of honing in on issues of intersectionality and resiliency. Gaining greater understanding about the nature of schizophrenia and other psychotic disorders requires the development of more effective strategies for treatment at the onset and with long-term chronic conditions. Evidence-based practice points to a combination of psychopharmacological and psychosocial interventions. The recovery model approach, based on hopes and lived experience, emphasizes the centrality of the individual's desires and initiative in relation to treatment planning.