Mediation and Moderation of Outcome in a Training Intervention for Adolescents With Attention-Deficit/Hyperactivity Disorder

Objective: A training intervention that aims to improve the problem-solving and organization skills of adolescents with attention-deficit/hyperactivity disorder (ADHD) has been investigated. Aim of this study was to examine the mechanisms of change that occurred during the intervention in an empirical trial. Method: Forty-nine adolescents with ADHD aged 12–17 years took part in the intervention. The primary outcome of the intervention was the reduction of ADHD symptoms. To understand how the intervention facilitated the improvement of the outcome, we conducted mediation and moderation analyses. As potential mediators, improvement in academic enablers and meta- and neurocognitive functioning were investigated. Age, gender, and medication status were analyzed as potential moderators of the outcome. Results: An improvement in academic enablers partially mediated symptom reductions. There were no effects of moderation. Conclusions: Enhancing academic skills can reduce ADHD symptom severity. The training intervention examined in this study is a promising treatment for adolescents with ADHD.