Although there are three types of human muscle tissue (striated, smooth, and cardiac), skeletal or striated muscle is the primary focus for the majority of chemodenervation procedures. There are many tissues in the body that are routinely investigated using ultrasound (US) including the tissues and structures relevant to chemodenervation. These tissues are discriminated by pattern recognition of their identifying features including the echogenicity and echotexture. Many other body tissues are also routinely evaluated with US including liver, spleen, kidney, heart, the infant brain, and others. The appearance of some tissues may also vary with the scanning plane, that is, longitudinal or transverse. These tissue differences allow experienced clinicians to distinguish between the various tissue types encountered when using US to guide procedures or during diagnostic scanning. The tissues of interest for chemodenervation include muscle, nerve, tendon, vessels, glands, as well as various organs which are to be avoided during procedures.