This chapter covers basic transducer handling and scanning tips/techniques that are required for clinicians to incorporate ultrasound (US)-guided chemodenervation procedures into their clinical practice. It provides a table presenting the advantages and disadvantages of ultrasound. To perform chemodenervation procedures (botulinum toxin [BoNT] injections, nerve/motor point blocks), clinicians must have a thorough knowledge of anatomy including: anatomical planes, cross sectional and functional anatomy. No localization technique, including sophisticated imaging guidance techniques such as US replaces this fundamental requirement. For clinicians to successfully implement US-guided chemodenervation techniques to their practice require a set of skills that are easily mastered with repeated practice. While developing this proficiency, physicians are encouraged to use US as an add-on to the guidance techniques with which they are comfortable. For many physicians, US largely replaces other guidance techniques once they have mastered this technology.