Opportunities for the use of virtual simulation in nursing education are vast, and the advantages for this teaching pedagogy are clear. Virtual simulations in nursing education use technology to provide safe and realistic simulation-based learning experiences (SBLEs) for nurses and nursing students. The use of virtual simulation in nursing education has been increasing in the past decade, but the evaluation of advantages of and opportunities for virtual technology integration and technology-enhanced healthcare simulation has only been explored in a fragmented manner as educators publish their own experiences with this educational pedagogy. This chapter explores the opportunities and advantages of virtual simulation and the integration of virtual technology in nursing education. Virtual simulation is a creative approach that provides interactive, engaging instruction. Virtual simulation, virtual patients, and virtual worlds are all valid tools applicable to nursing education in both the academic and practice setting.