The topic of work analysis is frequently given very limited coverage in textbooks related to occupational development, vocational behavior, rehabilitation counseling, and other rehabilitation healthcare fields; this is truly unfortunate. A comprehensive understanding of the requirements of work is essential to the career development and employment of individuals with disabilities; work analysis provides the foundation for building organizational processes that are effective, inclusive, and legally defensible. This chapter provides the reader with a thorough understanding of work analysis through coverage of its definition, history, methodological considerations, and applications. The workplace of today is a very different entity from what existed just a decade ago. Work analysis is a systematic process used to understand the nature of work. Although there are many methodological considerations to be contemplated and numerous existing work analysis tools available to the practitioner, the methods chosen must be appropriate for the purposes at hand.