Intensive care unit (ICU) rehabilitation is a developing practice for patients who are critically ill. Survivors of critical illness frequently experience many long-term sequelae, including ICU-acquired muscle weakness (ICUAW), which can occur in a quarter to half of critically ill patients. There is growing literature around the efficacy, safety, and quality of providing rehabilitation services in the ICU setting. Critically ill patients suffer with impairments that affect their cognitive and mental health, physical functioning, and quality of life. Prolonged time in bed is associated with ICUAW and several factors contribute to this ongoing barrier. These include the patient, their environment, the ICU culture, and other process-related issues. Multiple strategies exist for successful implementation and include therapy, nursing, physician champions, safety criteria guidelines, and interdisciplinary team approach around coordination and communication to address perceived barriers. ICU rehabilitation addresses the adverse effects of immobility and bedrest many experience due to illness.