Interventions can take place in a multitude of places—global locations, long-term care facilities, public health and military settings, schools, and hospitals—the list is as varied as the people for whom we develop these interventions. This chapter highlights just a few of these settings. It discusses conducting interventions in global settings, long-term care settings, public health settings, school settings, palliative care settings, and acute care settings. The chapter also provides some commonsense advice and overall perspectives from investigators whose work has been conducted in these specialized settings with strategies that facilitate success. There are a variety of long-term care settings, but the chapter focuses on congregate housing in which residents require some degree of assistance with their activities of daily living. The school setting is an ideal place to conduct intervention studies that focus on community-based health problems of youth.