This chapter describes how grounded theory (GT) was used in two separate studies on caregiving and long-term care (LTC) decision making, and explicates in detail the critical techniques of the method that required adaptation while simultaneously remaining true to the tenets of GT. The first study, “Caregiving in Rural African American Families for Elderly Stroke Survivors”, was a dissertation study. The second study “Caregiving Transitions: Long-Term Care Decision-Making in Rural African American Families”, was funded 2 years after the completion of the author’s dissertation. The theoretical framework that guided the two studies was symbolic interactionism. In both studies, recruitment difficulties impacted theoretical sampling and the simultaneous and cyclical nature of data collection and data analysis, which is one of the major hallmarks of GT research. New developments help to conduct GT research in a practical and realistic manner.