This chapter argues that nurses’ ability to reclaim its focus on health promotion and caring will be critical to their ability to provide for a culture of health in the United States in the years to come. Beginning with the 2001 attack on New York’s World Trade Center, it discusses significant events that had an impact on nursing during the first 16 years of the new century. The chapter focuses on select events of historic nature, including the September 11, 2001, attack on the World Trade Center; military nursing in the Iraq War; the problems of the nursing shortage and an aging population; nurses’ role in the response to Hurricane Katrina in 2005 and the influenza epidemic in 2009; and the Flint, Michigan, water crisis that began in 2014. It ends with “Reflections on History”, highlighting the words of historian Julie Fairman in 2016.