This chapter focuses on mindfulness as a psychological trait and presents a brief review of the evidence supporting the mindfulness-based and mindfulness-influenced therapies, which have emerged over the past 35 years. Mindfulness is a central element of third-wave cognitive therapies such as mindfulness-based stress reduction (MBSR), acceptance and commitment therapy (ACT), dialectical behavior therapy (DBT), and mindfulness-based cognitive therapy (MBCT). There is a substantial evidence base for the use of mindfulness in therapy for mood disorders, borderline personality, and even some evidence for chronic pain. Despite the fact that there is a sound theoretical basis for delivering a mindfulness-based intervention in a hypnotherapeutic context, there are no current empirical trials to demonstrate the outcome of such an approach. The chapter presents sample case study and hypnosis script to serve qualified clinicians as a template for implementing a combined mindfulness and hypnosis approach.