Cancer incidence increases with age, and in a little more than 10 years, 70% of cancer survivors will be over the age of 65. Many older adults have comorbid conditions and complex healthcare needs, such as physical health decline, falling, and decreased independence in activities of daily living, putting them at risk for rehabilitation needs as they prepare for or recover from various cancer treatment protocols. This chapter highlights some of the common problems that may impact upon the rehabilitation of the older adult with cancer and discusses a population specific approach to addressing these issues. The common problems are frailty, dementia, delirium, pain management, depression, sleep, polypharmacy, nutrition, comorbidities, mobility and falls. The goals of rehabilitation in the management of the older adult with cancer include providing older adult sensitive care, symptom management, maximizing functional ability and comfort to enhance quality of life while providing patient and caregiver safety.