This chapter discusses the exploration, measurement, and evaluation of confidence through the use of the transcultural self-efficacy tool (TSET). It highlights major components, features, and psychometric properties of the TSET. The TSET was originally designed to measure and evaluate students’ confidence for performing general transcultural nursing skills among diverse populations. Content validity was established by six doctoral-prepared nurses certified in transcultural nursing. Transcultural experts and educational leaders continually attest to the importance of the affective learning domain on integrating foundational and key professional values within a professional education. Novice learners will have lower self-efficacy perceptions than advanced learners. The high levels of internal consistency within the whole TSET instrument and within each subscale supported the use of scores for data analyses. Cultural competence of health care providers is a worldwide concern and the TSET has the potential to assist educators in evaluating cultural competence education initiatives.