Mindfulness practice hones our ability to notice those internal changes that occur when events or experiences cause us discomfort, excitement, pleasure, or pain. Mindfulness skills can provide a kind of rubric to follow in order to avoid reacting unconsciously, habitually, or impulsively because it is from our reactive, impulsive, habitual responses that people find themselves suffering from a cascade of unintended consequences. Mindfulness keeps us alert to our internal climate changes. In health care, mindfulness can cultivate within us a desire to know and understand the thoughts, feelings, and needs of patients and their families. Emotions are important informants of our internal state. Distress tolerance is the skill that every clinician can apply when health care situations impose strong emotion mind activation, especially in situations where people need to continue to operate effectively at work.