Holism focuses on unity, mutuality, meaning, and the interrelationship of all beings, events, and things. Holism is the theoretical and philosophical foundation for all complementary integrative healing modalities. Holistic integrative therapies can be used by the nurse, client/patient, and family. This chapter introduces the reader to a variety of holistic modalities that are used in nursing practice today and can be used in palliative care. It should be noted that centering, relaxation, imagery, meditation, reminiscence and life review, and journal writing are basic and can be practiced by nurses and students with little or no experience. The sense therapies, touch therapies, and Reiki body work necessitate further study. Whenever one learns these therapies, it is imperative that nurses practicing in palliative and hospice care be familiar with healing modalities and their beneficial effects for patients and families during the illness experience.