The National Institutes of Health (NIH) mission focuses on biomedical and behavioral research that was heavily centered on the etiology of diseases, mechanisms of spread and injury, and appropriate therapies. This chapter examines the context and processes surrounding the establishment of the National Institute of Nursing Research (NINR) at the NIH. The Shamian, Skelton-Green, and Villeneuve model, entitled “From Talk to Action” is utilized to understand the political legislative process and the professional context surrounding the NCNR/NINR’s creation. The model’s stages and steps are created to lead to health policy change. The initial stage, getting to the policy agenda, includes five steps: values and cultural beliefs, emergence of problems or issues, knowledge and research development, public awareness, and political engagement. The second stage consists of three steps, including interest group activation, public policy deliberation and adoption, and regulation, experience, and revision.