For a sexual problem to be considered a sexual dysfunction, the symptoms must be present for at least 6 months, cause significant distress, and cannot be caused exclusively by a nonsexual mental disorder (e.g., substance use, depression), significant relationship distress, medical illness, or medication. The three cases in this chapter represent various sexual dysfunctions, such as female sexual interest/arousal disorder and erectile dysfunction disorder, and their respective treatment. Questions for consideration follow each case.