Schizophrenia is a chronic, severe mental disorder that affects the way a person thinks, acts, expresses emotions, perceives reality, and relates to others. While uncommon as compared to other mental disorders, it is often the most chronic and disabling. This chapter contains three cases of schizophrenia spectrum disorder and other psychotic disorders, including delusional disorder of two types. These cases highlight disorders that cause various degrees of distress and dysfunction in three adult males. Questions for consideration are included.