Entering or reentering the workforce can be a challenging task for individuals following disabilities. Appropriate use of vocational interest measures in career counseling, however, can facilitate this process. This chapter reviews and familiarizes the readers with the construct of vocational interests, to update them with the most recent advances and new findings in interest research, especially with regard to gender differences in interests and the relationship between interests and performance. It provides a brief description of appropriate interest measures for rehabilitation counseling, their psychometric properties, and their usage. The assessment of interests is the starting point and a critical component in career counseling for clients with disabilities. Following interest assessment and assessments of other important individual characteristics, such as work values, aptitudes, and skills, additional information and resources are provided based on clients’ needs to facilitate their career entry or reentry after disabilities.