In the global health partnership process identified by Leffers and Mitchell, nurse partner factors include cultural perspectives, personal attributes and expectations, and knowledge of the host country. This chapter explores these nurse factors from the perspective of the nurse as an individual and the nurse situated within an organization. Compassion, curiosity, and courage have been identified as principles of program development in global service-learning programs. Attributes and expectations intrinsic to the nurse are essential to developing a successful global partnership. Clarifying the nurse’s role within the organization provides the boundaries of the partnership, and knowing what to possibly expect on arrival and throughout the partnership facilitates ongoing understanding of the partners within the context. The standards of practice for culturally competent nursing care relevant to global health partnerships include: Social justice, Critical reflection, Knowledge of cultures, and Cross-cultural communication.