This chapter focuses on the current and future potential implications of chronic ambulatory intracranial electroencephalography (CAIEEG). CAIEEG is capable of providing diagnostic information which can significantly change clinical management, especially in patients with possible or definite bitemporal epilepsy. While primarily being developed for more direct clinical applications, CAIEEG provides an excellent platform for research on cortical activity, which can now be conducted longitudinally in humans. CAIEEG is an ideal setting for seizure prediction research, as it provides the durability for the longitudinal study necessary to develop and test such prediction algorithms. It provides the advantages of longitudinal monitoring in an environment free of acute confounding factors with the high sensitivity and spatial resolution and minimal artifact of intracranial EEG recordings. Longitudinal research studies will deepen our knowledge of the electrical activity of the brain, and these new insights may drive future areas of research.