This chapter provides the nonspecific factors that are closely associated with psychotherapy outcomes. It explores what factors are linked to the relationship between client and therapist: working alliance/therapeutic alliance. The chapter also explores the most important factors for the development of the therapeutic alliance: empathy, emotional attunement, and unconditional positive regard. It outlines the different modes of therapeutic action in the expressive-supportive continuum. The chapter also provides the meaning of “frame” and its factors within the context of the therapeutic relationship. It discusses the pros and cons of self-disclosure and empathy. The chapter describes Carl Roger’s core necessary conditions for psychotherapy: congruence, unconditional positive regard, and accurate empathy. It then explains the different rupture-repair interventions that play an important role in restoring the therapeutic alliance. Building a strong therapeutic alliance is integral to counseling, but there are times when the alliance changes during treatment.