The dynamics of caregiving are the forces that motivate caregivers and care recipients to assume and continue the caregiving relationship. Unpaid care provided by family, friends, or neighbors is a critical resource in today’s health care system. Just as nurses are the health care providers who have the most contact with patients, they also have the most contact with caregivers. In this middle range theory of caregiving dynamics, caregiving refers to the care given by family, friends, or neighbors. The clinical situation that stimulated the development of this theory was the need to identify strategies to ensure reliable caregivers for patients scheduled to undergo hematopoietic stem cell transplantation (HSCT). The major concepts of the theory of caregiving dynamics are commitment, expectation management, and role negotiation. Commitment is enduring caregiver responsibility that inspires life changes to make the patient a priority.