Developing and delivering online courses can feel especially overwhelming when little or no guidance or support is provided. Instructors bring their own strengths as well as their deficits to the online learning environment, where some of these strengths and deficits are magnified. Online teaching requires planning, focus, diligence, thoughtfulness, and attention to detail to the curriculum and instruction. This chapter explores the variables that can ultimately determine the success of the instructor and offers strategies that help instructors manage their thoughts/emotions and mediate stress. The strategies serve as a platform for exploring strategies to allay fear and anxiety. Practical strategies such as Prepare, Assert, Consistent, and Embrace technology (PACE) and the ABC Model are good options for instructors seeking solace to unmanageable stress. Finally, instructors must demonstrate they CARE if students are to succeed and experience online learning for what it truly is a viable vehicle to accessible education.