The topic of abuse is something that cannot be confined to one organ system or patient visit type. Child abuse, domestic violence, elder abuse, and sexual abuse are serious and preventable public health problems that affect millions of people. Clinicians across all disciplines need to be well informed about the signs and symptoms of abuse in patients across the lifespan. The approach to the patient history and physical examination will vary based on the patient’s age, type of abuse suspected, and practice setting. However, there are specific steps that clinicians can follow to ensure comprehensive and compassionate care to their patients when faced with these difficult situations. This chapter helps the reader to distinguish between abusive injuries and accidental injury patterns in infants and children; understand the concept of the sentinal injury and review common sentinel injuries; and review the inherent challenge to recognition of abusive injuries.