Wicked problems occur not just for patients in healthcare services but also for nurses in attempting to change and improve their own professional culture. Nursing’s advancement and professionalization has been hampered by internal and external tensions, including professional disunity, public misunderstanding and devaluation, and lack of political will and support to improve conditions. This situation leads to further problems, such as stress, conflict, and burnout, and defensive coping mechanisms that can metamorphose into uncaring behaviors toward patients. This chapter focuses on these “wicked” problems of stress, burnout, and conflict. Nurses work in very busy environments, with many colleagues, each with a pressing job to do. When conflict or tension occurs, rather than take a blaming approach to the individual, it is much more productive to try to reflect on possible sources of rising tension.