Self-reliance has been noted by Native American leaders to be the mainstay and way of life that influence the health among Native American people. The purpose of the middle range theory of Self-Reliance is to articulate a process for promoting well-being with attention to appreciation for one’s culture. Self-reliance is being true to self and is lived by being responsible, disciplined, and confident while staying connected to one’s cultural roots. The three concepts of self-reliance are (a) being responsible, (b) being disciplined, and (c) being confident. The Theory of Self-Reliance has roots in Native American culture and values. It has grown over time as a foundation guiding the Talking Circle intervention used in nursing research, practice, and education. The middle range theory of Self-Reliance in this chapter is an expression of invitation to nurses who may choose to use the theory for practice, research, and education.