Palliative care is specialized medical care for people with life-limiting illness. The goals of palliative care are to improve symptom management, assess and support caregiver/family needs, and assist with care coordination. Palliative care consultations are appropriate for many hospitalized patients to provide extra support for the patient and family. Nurse practitioners should be discussing palliative care with patients and families when death within a year would not be surprising, and consider hospice when patients decline such that prognosis is likely to be death within 6 months. In fact, palliative care is increasingly being included in clinical practice guidelines as best practice. This chapter will help the Adult-Gerontology Acute Care Nurse Practitioner (AG-ACNP) learn overview of palliative care, key communication strategies, and SPIKES protocol for family meetings. It also helps the AG-ACNP learn the signs of the dying process, and symptom-management interventions.