This chapter focuses on finding the best evidence about a good clinical problem, so that one can establish what is already known about it and what still needs to be determined. The following reflective questions organize learning for this chapter: With which of the following are you the most comfortable?; What makes a good systematic literature review?; What does the concept of information literacy mean to you and why is this relevant to your project proposal?; What are the best strategies for completing a systematic literature review?; What evidence makes the best evidence?; What does it mean to complete a reference matrix?. A good literature review is one that is systematically documented, synthesized, and situated in the context of the professional literature. Identifying gaps can help make the case for your additional project work. The chapter summarizes the additional ways the literature will be useful in your project proposal.