Entering the world of grant writing and being successful in acquiring funding requires knowledge and skill. It also requires having appropriate institutional supports or an infrastructure that supports the pursuit of funding as well as performing the proposed activities of a project, if funded. To have a successful and long career in grant writing, an investigator must either be situated in a supportive environment or create one. In fact, funding agencies and review panels will evaluate whether an environment is adequate to support the proposed project. This chapter first examines the key factors that can serve as barriers to successful grant writing and identifies strategies to overcome potential limitations. The chapter then considers the core components of a supportive environment for pursuing grantsmanship. The chapter helps the reader identify common barriers to grant writing and describes the support needed to be successful in grant writing.