Caring for the geriatric population can be a challenging endeavor, especially when considering the numerous issues that they may have to cope with on a daily basis. This chapter reviews the topic of medication adherence and describes several promising technologies aimed at improving such within the larger scope of medication therapy management (MTM). These tools at our disposal today greatly benefit our elderly population in particular, by better equipping them to manage their chronic health conditions and addressing their unique challenges. As improvements in adherence monitoring technology become more affordable and available, the business of health care will evolve into a more integrated enterprise between patients and their health care providers. Although the future direction and successful impact of many of these adherence technologies looks promising, they will only be possible if both medical and nonmedical professionals find ways to safely and effectively adopt them.